Carbon Monoxide Danger?

I have a woodshop in my basement that is totally enclosed with no windows and no ventilation into or out of the room. The room is @ 15'x15'. Would it be a danger to have a hole cut in the wall for a powered ventilation system to exhaust from? The house has gas heat and the furnace is 2 rooms over past a hallway. I seem to remember whole house fans and gas furnaces do not play together not sure if this is the same thing.

The problem with the huge whole house fan is that it can depressurize a house which can cause a naturally drafted combustion appliance to backdraft into the house. The flue gas of a typical gas furnace (or boiler or water heater) contains some CO, typically less than 25 PPM, which would then be diluted with air, if it backdrafted. It takes hundreds of PPM of CO to kill you, depending on concentration and how long exposed.
If your furnace is a natural draft furnace (relies on hot air rising and goes up a chimney), an exhaust fan in your wood shop would probably not affect the draft. If your furnace is sealed combustion (takes its combustion air from outside and exhausts through the wall), then it will definitely not affect the furnace.
FYI, at best, a CO alarm will never alarm at a level below about 35 PPM, and a digital one will never indicate a level below about 25 PPM (it will show a zero for levels below 25). Only a more expensive (>>$100) calibrated CO detector will show levels starting at 1 PPM. Prolonged exposure to low levels of CO can make you feel tired.

My main gas furnace is a high efficiency unit with a PVC pipe for exhaust. I have another attic unit that is traditional 85% efficient. I was thinking of basically a dryer exhaust style vent hole in the woodshop venting directly outside with a ventilation system using it to move air outside.

If you do a lot of dust watch out for clogging the furnace fins if you are dont get the combustion air from outside. My friend with a woodshop clogged his furnace and we had to add an intake from outside.